How to Get Infected Blood in Resident Evil Requiem (RE9)

by Mark Smith · April 26, 2026

TL;DR

Infected Blood is Grace’s core crafting resource — Leon does not use it.
You need the Blood Collector first — found in the Blood Lab, East Wing of the Care Center.
Collect Infected Blood from zombie corpses, blood buckets, bathtubs, and Transfusion Bags.
Headshots and kneecap shots leave larger blood pools — always aim there.
The default Blood Collector cap is 100 units. Upgrade it to 150 with the Override Manual (6 Antique Coins) and to 200 permanently with the Master Manual (1,000 CP after completing the game).
Unlock crafting recipes by analyzing Blood Specimens at the Blood Analyzer in the Blood Lab.

Table of Contents

What Is Infected Blood in Resident Evil Requiem?

Infected Blood is the main crafting material for Grace in Resident Evil Requiem. It replaces the standard gunpowder-and-scrap system that Leon uses. Almost every useful item Grace can craft requires Infected Blood — from Handgun Ammo to Med Injectors to Hemolytic Injectors and even the powerful 12.7x55mm Requiem Bullets.

The system is unique to Grace. Leon cannot collect Infected Blood and does not use the Blood Collector at all. His crafting is separate and simpler — he combines Scrap and Gunpowder. This means that as Grace, managing your Infected Blood supply is one of the most important things you can do throughout the Care Center and Basement sections of the game.

If you ignore it, you will run out of ammo and healing options fast. If you manage it well, Grace becomes one of the most resourceful characters in the series.

How to Get the Blood Collector

You cannot collect Infected Blood until you have the Blood Collector tool. Here is exactly how to get it:

Unlock the East Wing Keycard to access the East Wing of the Care Center.
Head into the Blood Lab inside the East Wing.
The Blood Collector is sitting inside the Blood Lab — pick it up as part of your natural story progression.

This is not missable. The Blood Lab is a required area and the Blood Collector is sitting right there when you arrive. Once you pick it up, blood pool locations across the entire map are immediately marked on your minimap with icons, making it much easier to track them down.

Need help getting to the East Wing? See our guide on the East Wing Keycard location.

collecting infected blood locations resident evil 9 requiem

All Sources of Infected Blood in Resident Evil Requiem

Zombie Corpses (Best Regular Source)

Every zombie you kill leaves behind a blood pool that you can collect with the Blood Collector. This is your primary and most consistent source throughout the game. The key thing to know is that how you kill a zombie affects how much blood it leaves.

Headshots leave a larger blood pool than body shots.
Kneecap shots — shooting out the legs to down a zombie — also leave significantly larger pools than chest shots.
Chest shots and generic kills leave the smallest pools.

So aim for the head or the knees whenever you can. Even on enemies you would normally ignore, a quick headshot before moving on means more Infected Blood available to collect.

Environmental Blood Sources (Consistent and Free)

The Care Center is full of passive blood sources that refill over time or sit waiting for you across the map. These include:

Blood pools on floors and in hallways
Overflowing bathtubs filled with infected blood
Medical buckets and blood containers scattered through the wards
Bloodstains on walls and operating tables in certain rooms

After picking up the Blood Collector, all of these are marked on your map automatically. Do a sweep of each area before moving on to top off your supply. See the full list of blood specimen and container locations in our blood specimen locations guide.

Transfusion Bags (Rare but Powerful)

Transfusion Bags are consumable items that instantly refill your Blood Collector to its maximum capacity in one use. They are rare and valuable — do not use them casually. Save them for moments when you are critically low on Infected Blood and cannot safely farm from the environment.

There are two reliable ways to find Transfusion Bags:

Locked drawers — Use Grace’s lockpicks to open drawers throughout the Care Center. Some contain Transfusion Bags alongside Rare Metal and other supplies.
Blind IV Stand Infected — These specific enemies drop a Transfusion Bag every single time you kill them. If you see a zombie dragging an IV drip and lacking eyes, prioritise killing it and collecting from it. It is the most reliable farming method in the game.

getting the blood collector resident evil 9 requiem

How to Upgrade the Blood Collector

The default Blood Collector holds a maximum of 100 units of Infected Blood. That sounds like a lot, but some of Grace’s best crafting recipes — like Steroids (120 units) and Stabilizers (130 units) — literally cannot be crafted at all without upgrading the cap first. This makes upgrading a priority, not an afterthought.

There are two upgrades available:

Override Manual — +50 Capacity (100 → 150)

The Override Manual is purchased from the Coin Cabinet in the Parlor, located in the West Wing of the Care Center. It costs 6 Antique Coins. Once used, your Blood Collector cap increases from 100 to 150 units permanently for that run.

Important: This upgrade does not carry over to a new playthrough. You need to buy it again with Antique Coins each time you start a fresh run. Collect your Antique Coins early so you can grab this before hitting the mid-game crafting wall. Check our Antique Coins and Parlor Prizes guide for every coin location.

Master Manual — +50 Capacity (150 → 200, Permanent)

The Matsuoka Master Manual is unlocked from the Special Contents menu after completing the game. It costs 1,000 Challenge Points (CP). Once purchased, this upgrade permanently raises your Blood Collector cap by an additional 50 units — to a total of 200 — and applies automatically to every playthrough going forward, including new game plus runs.

With both upgrades active, a full Blood Collector holds 200 units. That is enough to craft multiple Stabilizers in a row without needing to stop and farm. Prioritise this purchase after finishing your first playthrough.

How to Unlock Crafting Recipes for Infected Blood

Having Infected Blood is useless without recipes to spend it on. Grace starts with almost no recipes. To unlock them, you need to find and analyze Blood Specimens using the laser microscope in the Blood Lab — or in the second-floor Office.

There are three Blood Specimens hidden in the Care Center. Each one unlocks a different set of recipes when analyzed:

Blood Specimen (Denatured) — Blood Lab

This is the first specimen you find, located inside the Blood Lab itself. Analyzing it unlocks:

Handgun Ammo crafting
Hemolytic Injectors — one of Grace’s most powerful tools. Three of them will silently kill the Chunk enemy in the East Wing. They also let you instantly stealth-kill isolated zombies without spending bullets.

Blood Specimen (Reversible) — Blood Lab Storage Room

This specimen is in the storage room directly adjacent to the Blood Lab. You need the Level 1 ID Wristband to access the security door. Analyzing it unlocks:

Steroids — permanently raises Grace’s maximum health
Stabilizers — permanently improves Grace’s gun handling and firepower

Note: Steroids cost 120 units and Stabilizers cost 130 units of Infected Blood each — you cannot craft either without first upgrading the Blood Collector above the default 100 cap. Get the Override Manual before attempting these.

Need the Level 1 ID Wristband? See our Level 1 ID Wristband location guide.

Blood Specimen (Converged) — Closet Near Waiting Room

This is arguably the most important specimen in the game. It is found in the closet next to the Waiting Room, also locked behind the Level 1 ID Wristband. Analyzing it unlocks:

Med Injectors — Grace’s healing item equivalent
12.7x55mm Ammo (Requiem Bullets) — the powerful rounds for the Requiem revolver, crafted using Rare Metal

This is the specimen that makes the Requiem self-sustaining as a weapon. Once you can craft your own Requiem Bullets, you are never truly out of ammo for Grace’s best gun. For the full guide on getting Requiem Bullets, see our Requiem Bullets guide.

Additional Recipes From Documents

Two more recipes are unlocked from written documents rather than Blood Specimens:

Molotov Cocktail recipe — found in the Bunkroom in the Care Center Basement
Acid Bottle recipe — found in the Monitor Control Room inside the ARK facility

For more on the Monitor Control Room, see our Monitor Control Room safe code guide.

What Can You Craft With Infected Blood?

Once you have the Blood Collector and your recipes unlocked, here is what Grace can craft using Infected Blood:

Handgun Ammo — Infected Blood + Scrap. The most common craft and your bread-and-butter for staying stocked.
Hemolytic Injectors — Infected Blood + Scrap. Instant stealth kills on zombies. Three kills Chunk.
Med Injectors — Infected Blood + Empty Injector. Grace’s primary healing item.
12.7x55mm Ammo (Requiem Bullets) — Infected Blood + Rare Metal. Powerful and limited — use them on bosses and Chunk.
Steroids — Infected Blood + Empty Injector. Permanently raises Grace’s max health. One-time use per stat cap.
Stabilizers — Infected Blood + Empty Injector. Permanently improves Grace’s firepower and handling. One-time use per stat cap.
Molotov Cocktails — Infected Blood + Empty Bottle. Great for groups of enemies and emergencies.
Acid Bottles — Infected Blood + Empty Bottle. Unlocked in the ARK section.

Grace has 16 total crafting recipes to discover. Unlocking every one contributes to the Master Craftsman trophy or achievement. See our full trophy and achievement guide for how to get every one efficiently.

What to Craft First — Priority Order

With a limited Blood Collector capacity early on, you need to spend wisely. Here is the recommended priority order for Grace’s Infected Blood spending:

Hemolytic Injectors first — Three of them silently kill the Chunk in the East Wing, saving you from wasting ammo on a dangerous enemy. They also let you handle isolated zombies without bullets.
Handgun Ammo — Once you are past the Chunk, craft ammo consistently to keep your handgun stocked. Never let scrap pile up unused.
Get the Override Manual before crafting Steroids or Stabilizers — You cannot afford these before the cap upgrade. Save your Antique Coins, buy the Override Manual from the Parlor, and then start crafting stat upgrades.
Med Injectors mid-to-late Care Center — Once you have the Converged specimen unlocked and a stable Infected Blood supply, start crafting healing items. Before that, rely on Green Herbs.
Requiem Bullets for boss fights — Save Rare Metal specifically for 12.7x55mm crafting before heading into major encounters like The Girl or Chunk as Leon.

Infected Blood Tips for Efficient Play

Never Leave a Room Without Checking the Map

After getting the Blood Collector, all environmental blood sources are marked on your minimap. Before moving on from any area, glance at the map and sweep nearby blood icons. A full collector going into a new zone means more crafting options and less backtracking.

Always Kill the Blind IV Stand Infected

These specific zombie variants drop a Transfusion Bag every time. A Transfusion Bag fills your entire Blood Collector instantly. Prioritise killing them whenever you see them — even if you would normally sneak past regular zombies to save ammo, the IV stand variant is always worth taking down.

Headshots and Leg Shots Yield More Blood

This is easy to forget in the middle of a tense encounter, but it makes a real difference over a full playthrough. Aim for the head or legs when possible. Body shots waste the extra blood yield. Even a quick aimed shot to the knee before finishing a zombie off gives you noticeably more resources per kill.

Upgrade Before Steroids and Stabilizers

The default 100-unit cap means you cannot craft Steroids (120 units) or Stabilizers (130 units) at all. Do not even attempt to save up for these before buying the Override Manual from the Parlor. Get your 6 Antique Coins first. See our Antique Coins guide to find them all.

The Minimalist Trophy Means No Blood Collector at All

If you are going for 100% trophies, one trophy called Minimalist requires you to complete the game without ever using the Blood Collector. This is tracked under Challenges and must stay at 0 uses for the entire run. You will need to plan a separate playthrough for this — do not try to combine it with a collectible run. For the full breakdown of the Minimalist trophy and every other achievement, see our complete trophy guide.

Related Guides

Resident Evil Requiem is available on PlayStation Store, Xbox, Nintendo Switch 2, Steam, and the Epic Games Store.

How to Get Infected Blood in Resident Evil Requiem (RE9)

What Is Infected Blood in Resident Evil Requiem?

How to Get the Blood Collector